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CD4-guided structured treatment interruptions safe in patients at high risk of resistance

Patients at high risk of developing drug resistance can undergo CD4-guided structured treatment interruptions without developing major HIV drug resistance mutations, according to a small

Published
09 February 2005
By
Christopher Gadd
Lowest-ever CD4 cell count can predict how long treatment can be interrupted

Interruption of antiretroviral therapy in HIV-positive patients leads to a larger fall in CD4 cell count in patients whose lowest-ever, or 'nadir' CD4 cell count

Published
01 February 2005
By
Christopher Gadd
ICAAC: Treatment breaks riskier if NNRTIs involved

Individuals who interrupt highly active antiretroviral therapy (HAART) that contains a non-nucleoside reverse transcriptase inhibitor (NNRTI), or resume HAART with an NNRTI, are more likely

Published
30 October 2004
By
Michael Carter
Treatment interruption results in lipid reduction; IL-2 has no effect on lipids

A structured treatment interruption in patients with moderately elevated lipid levels resulted in lipid reductions of 15 to 20% that were sustained for over one

Published
28 October 2004
By
Keith Alcorn
Treatment interruption 'safe' in those with lowest-ever CD4 counts above 250 cells/mm3

The majority of individuals whose lowest-ever CD4 cell count did not fall below 250 cells/mm3 appear able to interrupt treatment safely, for at least one

Published
26 October 2004
By
Edwin J. Bernard
Pilot study finds weekend breaks from HAART may be possible on NNRTIs

An intriguing study presented on the second day of the Fifteenth International AIDS Conference examining the feasibility of intermittent therapy taken five days a week,

Published
14 July 2004
By
Edwin J. Bernard
CD4-guided treatment interruptions safe and cost-effective, Thai study shows

The final results of a small Thai study have shown that using CD4 cell counts to guide treatment interruptions is a safe way to reduce

Published
14 July 2004
By
Christopher Gadd
Short-cycle intermittent HAART maintains undetectable viral load, but does not increase CD4 counts

A small proof-of-concept study has shown that once-daily treatment with ddI (didanosine), 3TC (lamivudine) and efavirenz in a week on, week off (WOWO) regimen effectively

Published
03 June 2004
By
Christopher Gadd
Stopping nevirapine five days prior to nucleosides may avoid resistance

Stopping the nevirapine component of nevirapine-based HAART five days prior to the nucleoside backbone when stopping or interrupting treatment appears to be a “reasonable strategy”

Published
20 May 2004
By
Edwin J. Bernard
Differences found between patients stopping HAART for medical or lifestyle reasons

HIV-positive individuals who take a break from their anti-HIV treatment for medical reasons have different motives and characteristics to patients who are motivated to temporarily

Published
04 March 2004
By
Michael Carter
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